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Thyroid Medication Guide

Dr. Ray Peat's approach to T3, T4 and natural desiccated thyroid — prescription medication explained

We do not sell nor prescribe medication

This guide is for those who want to know more about the best types of thyroid medication. If you do not have a prescription for thyroid hormone, our Natural Desiccated Thyroid Guide can help you find good brands of over-the-counter (OTC) thyroid supplements.

Best thyroid medication — Ray Peat approach

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Thyroid medication advice

Our thyroid medication recommendations are based on the research of Dr. Ray Peat, a world-leading thyroid expert.

According to Dr. Ray Peat, a good thyroid medication should contain both thyroid hormones — T4 and T3 — simulating the natural hormone production of the human thyroid gland. Both natural and synthetic thyroid medications containing T4 and T3 are available, however, most doctors prescribe only synthetic T4, which can create serious problems. This guide discusses all the important aspects of thyroid replacement therapy.

This guide includes information on

  • The importance of using combination therapy with both T4 and T3.
  • The problem with T4-only treatment.
  • Prescription Natural Desiccated Thyroid.
  • The story of Armour Thyroid.
  • The best Natural Desiccated Thyroid brands.
  • Synthetic thyroid replacement therapy.
  • Strength conversion between natural desiccated thyroid and synthetic thyroid products.
  • Why Dr. Ray Peat usually recommends synthetic thyroid medication.
  • The best synthetic thyroid medication brands.
  • What is a normal daily dosage of thyroid hormone?
  • How to use thyroid replacement therapy.
  • Why do some people need extra T3?
  • Dosage examples of synthetic and natural thyroid products.
  • Why it is necessary to go slow when starting thyroid medication.
  • How to use pulse, temperature, and symptoms to evaluate the effect of your thyroid medication.
  • How increasing your metabolism can reveal a nutritional deficiency.
  • Why some people have negative symptoms upon starting thyroid replacement therapy.
  • How progesterone and pregnenolone can help stabilize your body while correcting thyroid function.

What is the best thyroid medication?

According to Dr. Ray Peat, the best thyroid medication should contain both T4 and T3 — not just T4 alone. This combination mimics the natural output of a healthy thyroid gland.

Both natural desiccated thyroid (NDT) and synthetic combination medications are covered in this guide, along with strength conversions, dosing strategies, and how to monitor your response.

Need guidance on thyroid medication?

Book a private consultation with Dr. Benedicte Lerche for personalised advice on finding and fine-tuning the right thyroid therapy for your body.

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